WebApr 3, 2024 · Of the five markers compared, TRPS1 seems the most sensitive marker for the mammary origin of CK5-expressing TNBCs, and has a place in breast marker panels. The lack of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 expression in breast cancer (BC) is the basis for the categorization of the … WebMar 1, 2024 · TRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast carcinomas. To further explore TRPS1's utility in breast carcinoma, we …
TRPS1: a highly sensitive and specific marker for breast …
WebAug 10, 2024 · Involved in breast cancer carcinogenesis and required for breast cancer cell survival Plays a critical role in the development of cartilage, bone and hair follicle ... WebThe TRPS1 gene provides instructions for making a protein that regulates the activity of many other genes. The TRPS1 protein is found within the cell nucleus where it interacts with specific regions of DNA to turn off (repress) gene activity. Based on this role, the TRPS1 protein is called a transcription factor. hdfc ach portal
Expression of TRPS1 in cancer - Summary - The Human Protein …
WebMar 11, 2016 · TRPS1 was frequently down-regulated in high-metastatic cancer cell lines from the breast, colon and nasopharynx. Silencing of TRPS1 stimulated epithelial–mesenchymal transition (EMT), migration and invasion in vitro and metastasis in vivo , while TRPS1 over-expression exhibited the opposite effects. WebFeb 15, 2024 · TRPS1 is a GATA-like transcription factor, which functions as a transcriptional repressor or activator, depending on cell type, stage of development, or pathological conditions. Based on this assumption, we explored additional roles of TRPS1 in tumor progression. WebJun 12, 2024 · The TRPS1 gene is very often amplified in breast cancer (28% of 2051 cases in the METABRIC cohort and 20% of 963 patients in the TCGA cohort) and its amplification is associated with worse ... hdfc account transfer online