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Trps1 breast

WebApr 3, 2024 · Of the five markers compared, TRPS1 seems the most sensitive marker for the mammary origin of CK5-expressing TNBCs, and has a place in breast marker panels. The lack of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 expression in breast cancer (BC) is the basis for the categorization of the … WebMar 1, 2024 · TRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast carcinomas. To further explore TRPS1's utility in breast carcinoma, we …

TRPS1: a highly sensitive and specific marker for breast …

WebAug 10, 2024 · Involved in breast cancer carcinogenesis and required for breast cancer cell survival Plays a critical role in the development of cartilage, bone and hair follicle ... WebThe TRPS1 gene provides instructions for making a protein that regulates the activity of many other genes. The TRPS1 protein is found within the cell nucleus where it interacts with specific regions of DNA to turn off (repress) gene activity. Based on this role, the TRPS1 protein is called a transcription factor. hdfc ach portal https://hj-socks.com

Expression of TRPS1 in cancer - Summary - The Human Protein …

WebMar 11, 2016 · TRPS1 was frequently down-regulated in high-metastatic cancer cell lines from the breast, colon and nasopharynx. Silencing of TRPS1 stimulated epithelial–mesenchymal transition (EMT), migration and invasion in vitro and metastasis in vivo , while TRPS1 over-expression exhibited the opposite effects. WebFeb 15, 2024 · TRPS1 is a GATA-like transcription factor, which functions as a transcriptional repressor or activator, depending on cell type, stage of development, or pathological conditions. Based on this assumption, we explored additional roles of TRPS1 in tumor progression. WebJun 12, 2024 · The TRPS1 gene is very often amplified in breast cancer (28% of 2051 cases in the METABRIC cohort and 20% of 963 patients in the TCGA cohort) and its amplification is associated with worse ... hdfc account transfer online

TRPS1 regulates oestrogen receptor binding and histone ... - Nature

Category:TRPS1 shapes YAP/TEAD-dependent transcription in breast

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Trps1 breast

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WebTRPS1 gene was responsible for most of the TRPS phenotype; Data show that co-silencing of tricho-rhino-phalangeal-syndrome (TRPS1) and cathepsin D (Cath-D) in breast cancer …

Trps1 breast

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WebSep 4, 2024 · Results. PVT1 expression was upregulated in breast cancer tissues and cell lines. In addition, PVT1 silencing inhibited breast cancer cell growth and motility, while … WebIn the current study, through TCGA data mining we identified trichorhinophalangeal syndrome type 1 (TRPS1) as a specific gene for breast carcinoma across 31 solid tumor types. Moreover, high mRNA level of TRPS1 was found in all four subtypes of breast carcinoma including ER/PR-positive luminal A and B types, HER2-positive type, and basal …

WebJun 30, 2024 · Correlation between TRPS1 expression and BCRP expression in breast cancer. Effects of TRPS1 on BCRP-Mediated Mitoxantrone Efflux Activity The functional efflux assay was based on the extrusion of mitoxantrone, high-affinity substrate of BCRP. WebJul 3, 2024 · The GATA transcription factor TRPS1 is abnormally up-regulated in breast cancer, osteosarcoma, prostate cancer, and other tumor tissues, and is instrumental in regulating cell proliferation, differentiation, and tissue growth and development. Methods

WebTRPS1 is commonly amplified in breast cancer, which suggests that restrained YAP activity favours tumour growth. High TRPS1 activity is associated with decreased YAP activity and leads to decreased frequency of tumour-infiltrating immune cells. Our study uncovers TRPS1 as an epigenetic regulator of YAP activity in breast cancer. WebAug 6, 2024 · TRPS1 is commonly amplified in breast cancer, which suggests that restrained YAP activity favours tumour growth. High TRPS1 activity is associated with …

WebMar 9, 2024 · TRPS1 is amplified/overexpressed in breast cancer and promotes breast carcinogenesis (A) Tissue array analysis for TRPS1 expression (left). ∗∗∗ p < 0.001; two-tailed paired t test. Representative images are shown (right). (B) Western blotting analysis of TRPS1 expression in the indicated cell lines.

WebMar 27, 2024 · TRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast carcinomas. To further explore TRPS1's utility in breast carcinoma, we systematically evaluated TRPS1 ... golden eagle feather tattooWebAug 6, 2024 · More information: Dana Elster et al. TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells, Nature Communications (2024). DOI: 10.1038/s41467-018-05370-7 Journal information: Nature ... hdfc ac openingWebAmong non-breast tumors, TRPS1 is only expressed in some cases of lung squamous cell carcinoma, urothelial carcinoma (2%), and ovarian adenocarcinoma. Therefore, TRPS1 … golden eagle fightlite mcr 12.5inchWebMay 5, 2008 · Individuals with TRPS1 may also exhibit other physical abnormalities including abnormal prominence of the breast bone (pectus carinatum), an unusual “wing-like” shape … hdfc acknowledgement statusWebJun 14, 2011 · Consistent with this, lower abundance of TRPS1 is a poor prognostic marker in breast cancer . The defects associated with TRPS1 mutation ( 31 ) are indicative of a … golden eagle ferry scheduleWebThe association between YAP1 and TRPS1 was primarily clarified by Elster et al, who suggested that YAP1 was downregulated, while TRPS1 was commonly amplified in breast cancer, and high TRPS1 activity was associated with decreased YAP1 activity, leading to decreased frequency of tumor-infiltrating immune cells. 15 Therefore, the present study ... golden eagle fightlite mcrWebTRPS1抑制SOX2在乳腺癌细胞干性维持和肿瘤发生起始的转录调控机制研究.pdf golden eagle ferry st charles