Topcat trial pubmed
Web9. sep 2016 · TOPCAT was a phase III, multicentre, international, randomized, double‐blind, placebo‐controlled trial. Patients were eligible if they were ≥50 years of age, exhibited at least one sign and one symptom of HF, and had an LVEF of ≥45%. WebThe primary outcome of the TOPCAT trial was a composite of cardiovascular mortality, aborted cardiac arrest, or heart failure hospitalization. Results: A total of 760 patients …
Topcat trial pubmed
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Web31. okt 2024 · TOPCAT was a multicentre, randomized, double-blind, placebo-controlled trial that tested the efficacy of spironolactone to reduce CV morbidity and mortality in 3445 adults ≥50 years of age with HFpEF (LVEF ≥45%). 5 Key exclusion criteria relevant to this analysis included severe lung disease requiring home O 2 or systemic steroid therapy ... Web4. apr 2024 · In the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, patients with heart failure and preserved ejection …
Web19. jan 2015 · Given the marked regional variation in event rates observed in the TOPCAT trial, we performed a separate pooled analysis, excluding patients randomized into TOPCAT trial from Russia and the republic of Georgia. WebTOPCAT enrolled patients with left ventricular EF≥45%, which is below accepted diagnostic cut-offs for HFpEF; sensitivity analysis restricted to patients with left ventricular EF≥50% …
Web17. júl 2024 · The Total or Partial Knee Arthroplasty Trial (TOPKAT) therefore aims to assess the clinical effectiveness and cost-effectiveness of TKR versus PKR in patients with … WebMethods and results: Using data from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, a frailty index (FI) was …
Web18. sep 2024 · The study design and principal results of the TOPCAT trial have previously been reported. 9 Briefly, this trial compared the use of spironolactone 15–45 mg daily with placebo in patients with symptomatic HFpEF. Overall, 3445 patients were randomized in …
Web10. okt 2024 · These trials include; PEP-CHF (perindopril)2, CHARM-Preserved (candesartan)3, I-PRESERVE (irbesartan)4, TOPCAT (spironolactone)5, and PARAGON-HF (sacubitril/valsartan)6. Sodium-glucose cotransporter 2 (SGLT2) inhibitor is a new anti-diabetic drug that reduces blood glucose levels through increased glucose excretion in … sandpaper wheel for drillWeb24. jún 2024 · As such, the National Heart, Lung, and Blood Institute sponsored the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial, a phase 3, international, double-blind, placebo-controlled trial of spironolactone in patients with HFpEF [ 8 ••]. shore jobs in shippingWebIn TOPCAT, women and men presented with different clinical profiles and similar clinical outcomes. The interaction between spironolactone and sex in TOPCAT overall and in the … sand parks near meWeb15. sep 2015 · The recently completed TOPCAT trial enrolled HFpEF patients with LVEF ≥45%. 6 Spironolactone did not reduce the primary outcome of heart failure hospitalization, ... Related articles in PubMed. Characteristics and outcomes in acute myocardial infarction hospitalizations among the older population (age =80 years) in the United States, 2004 ... shore jobs in the navyWeb2. aug 2016 · More recently, spironolactone has been evaluated in the National Heart, Lung, and Blood Institute (NHLBI) sponsored TOPCAT trial 26 in which 3445 patients with chronic HF with a preserved left ventricular ejection fraction (HF-PEF) were randomized to spironolactone in a dosing strategy starting with 15 mg/day with possible up titration to … shore jobs in shipping companiesWeb10. apr 2014 · Methods: In this randomized, double-blind trial, we assigned 3445 patients with symptomatic heart failure and a left ventricular ejection fraction of 45% or more to … sandpaper to smooth metalWeb26. sep 2015 · Recently, the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) study, a randomized, double-blind clinical trial of spironolactone versus placebo, was conducted in 3445 patients with symptomatic HFpEF. sandpark service station