Spic macrophage
WebActivated macrophages must fine-tune their inflammatory responses to promote host defense while limiting tissue damage. Alam et al. find that the transcription factor Spic restrains inflammatory responses and promotes iron efflux from activated macrophages, thereby calibrating macrophage responses during the resolution of inflammation. WebAug 29, 2005 · The expression of spiC is down-regulated in NO-producing, IFN γ -treated macrophages We next tested whether NO produced by IFNγ-treated macrophages decreases intracellular SPI2 transcription. PCR analysis revealed that s piC expression was inhibited selectively in J774 cells treated with IFNγ.
Spic macrophage
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WebJan 24, 2024 · Macrophages are prominent cells of the innate immune system characterized by their high phagocytic capacity and the ability to process antigens. While best known for their roles in controlling immune …
WebAug 14, 2024 · Intestinal CX 3 CR1 high Mϕs highly expressed Spi-C in a heme-dependent manner, and myeloid lineage-specific Spic -deficient ( Lyz2-cre; Spicflox/flox ) mice showed severe intestinal inflammation with an increased number of Th17 cells during dextran sodium sulfate-induced colitis. WebRed pulp macrophages are a distinct splenic subset involved in removing senescent red blood cells. Transcription factors such as PU.1 (also known as Sfpi1) and C/EBPa (Cebpa) have general roles in myelomonocytic development, but the transcriptional basis for producing tissue macrophage subsets remains unknown.
WebDec 14, 2024 · Like T cells, macrophages are another type of immune cell, which is recruited to wounds to patch them up. With cancer, macrophages are recruited to tumor sites, … WebAug 7, 2024 · SpiC was the first SPI2-encoded protein to be identified that could be secreted by the Spi/Ssa T3SS2 system into the macrophage cytoplasm (Ochman et al., …
WebJan 15, 2009 · Spic (-/-) mice have a cell-autonomous defect in the development of red pulp macrophages that is corrected by retroviral Spi-C expression in bone marrow cells, but …
WebNov 11, 2002 · To address the relevance of the SpiC–TassC interaction during the natural course of Salmonella infection, J774 macrophages were infected with a wild-type and a spiA deletion Salmonella strain which does not secrete SpiC. Infected macrophages were fractionated by digitonin extraction, which is an accepted method for selective … luton v grimsby free streamWebMar 13, 2014 · Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-associated iron. The transcription factor SPI-C is selectively expressed by RPM and is required for their development, but the physiologic stimulus inducing Spic is unknown. Here, we report that Spic also regulated the development of F4/80 + VCAM1 + … jds service companyWebApr 29, 2024 · Macrophages are mononuclear cells functioning as professional phagocytes to remove dying, dead or harmful pathogens. Macrophages are a type of white blood cell … jds security servicesWebNov 25, 2015 · Macrophages are key components of the innate immune system that reside in tissues, where they function as immune sentinels. They are uniquely equipped to sense … jds seed in orrville ohioWebAug 11, 2015 · A main function of splenic red pulp macrophages is the degradation of damaged or aged erythrocytes. Here we show that these macrophages accumulate ferrimagnetic iron oxides that render them... luton v middlesbrough predictionWebMay 18, 2024 · Corroborating that, Spic restrains inflammatory response in macrophages and is induced via toll-like receptor (TLR) signaling in monocytes ( 10, 12 ). Alam et al. have demonstrated that Spic has a role in the transcriptional circuit within activated macrophages by sensing its inflammatory milieu ( 10 ). jds septic servicesWebmacrophages to induce, downmodulate, direct and orchestrate the proper action of the immune system. Imagine how many therapeutic possibilities will open once new targets … luton v reading head to head