WebAbout Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features NFL Sunday Ticket Press Copyright ... Webthree S4 residues — R365, R368 and R371 — make a sig-nificant contribution. Q was also altered by neutralising residue E293 of helix S2, suggesting that S4 might interact with S2. Other mutagenesis studies, however, showed that changing neutral residues of S4 — alterations that leave its charge unaltered — can also modify the channel gating

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