Pyrilutamide (developmental code name KX-826) is a nonsteroidal antiandrogen (NSAA) – specifically, a selective high-affinity silent antagonist of the androgen receptor (AR) – which is under development by Suzhou Kintor Pharmaceuticals, inc., a subsidiary of Kintor Pharmaceutical Limited, for the potential … See more Pyrilutamide successfully completed phase II clinical trials in China and is currently in phase II clinical trials in the U.S for the potential treatment of androgenetic alopecia in males. It is currently in phase II … See more Pharmacodynamics Pyrilutamide binds to the androgen receptor with a very high affinity with an IC50 of … See more Pyrilutamide is generally well-tolerated. The most common adverse event is contact dermatitis. See more WebJul 31, 2024 · KX-826 topical solution will be applied to the scalp of healthy male subjects with androgenetic alopecia. A total of 40 subjects will be evaluated with 32 subjects randomized to receive active drug and 8 subjects randomized to receive placebo in a double-blind fashion (10 subjects in each dose cohort with 8 subjects randomized to …
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WebAug 29, 2024 · The important statistical data results from Kintor’s KX-826 pyrilutamide phase 2 trial in males is: The trial comprised 120 male subjects with Norwood levels of 3V, 4, and 5. Cohorts included KX-826 2.5mg BID, 5mg QD, 5mg BID, and Placebo QD, BID. Primary endpoint was non-vellus target area hair count (TAHC) change from baseline to … WebFor those who don’t know pyrilutamide also known as KX-826 is an androgen receptor antagonist similar to CB-03-01 or RU58841 but Pyrilutamide has a stronger binding … family law attorney huntersville nc
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WebNov 11, 2024 · In rare cases, medications that contain the following ingredients can also cause hair loss during the anagen phase: arsenic. bismuth. boric acid. thallium. Colchicine (Colcrys), which doctors use ... WebApr 7, 2024 · What KX-826 is: "KX-826 is an androgen receptor (AR) antagonist and a potential first-in-class topical drug for the treatment of androgenetic alopecia (AGA) and acne vulgaris." It's a topically-applied treatment that binds to androgen receptors in the hair follicles, effectively blocking DHT from binding and causing hair loss. WebJul 30, 2024 · Pyrilutamide; KX-826; Placebo Comparator: Control Group- Placebo Placebo is tropically applied to the scalp of healthy male subjects with Androgenetic Alopecia with a single dose. Other: Placebo Placebo of KX-826. Outcome Measures. Go to cookware types