Nucleophosmin inhibitor
Web13 jan. 2024 · Nucleophosmin (NPM), encoded by the NPM1 gene, is a ubiquitously expressed phosphoprotein residing predominantly in the granular component of the … Web31 jan. 2011 · Nucleophosmin (NPM) is a multi-functional cellular chaperone. NPM is the product of the NPM1 gene, which in humans contains 12 exons and maps to …
Nucleophosmin inhibitor
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Web4 okt. 2024 · ImmuPharma is developing IPP 204106, a nucleolin and nucleophosmin inhibitor, primarily for the treatment of cancer, initially solid tumours. Nucleolin is a IPP 204106 Next Previous Table of Contents At a glance Development Overview ... Web23 uur geleden · Combinatorial approach using covalent menin inhibitor, BMF-219, and/or covalent FLT3 inhibitor, BMF-500, with MEK or BCL2 blockade potentiates therapeutic use in AML. Session Category ... Mutations in epigenic modifiers, nucleophosmin (NPM1c), signaling and kinase pathway such as KMT2A-re-arrangements (KMT2A-r), internal …
WebHere, we show that the BRD4 bromodomain inhibitor JQ1 is highly active against the p53-wild-type Ontario Cancer Institute (OCI)-AML3 cell line which carries mutations in … WebIC50: 1.7-4.0 μM for tested cancer cell lines. NSC348884 is a nucleophosmin inhibitor. Nucleophosmin is identified as a multifunctional nucleolar phosphoprotein, which is dysregulated in human malignancies resulting in anti …
WebIn the present study, beef samples were incubated with the inhibitor of Prdx6 (NSC348884) or/and H 2 O 2 to regulate the level of Prdx6. NSC348884, a small-molecule inhibitor of nucleophosmin (NPM ... WebNational Center for Biotechnology Information
Webp53 inhibitors (inhibiting targets of signaling pathways) used for various assays, some have entered clinical trials, which would be new cancer therapies. ... NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM. Nat Commun, 2024, 3;11(1):1669
Web1 feb. 2024 · The nucleophosmin 1 (NPM1) protein is frequently overexpressed in various cancers compared to normal tissues and represents a potential biomarker for … trusted care chinnorWebNucleophosmin is a protein that in humans is encoded by the NPM1 gene. Background The multifunctional protein Nucleophosmin (NPM), also known as B23, N038, … philipp wilhelmy hahlenWeb23 jan. 2014 · Inhibition of B23 in the HepG2.2.15 cell line reduces HBV replication. To analyze the role of B23 in HBV replication cycle, the extracellular and intracellular HBV DNA levels were quantified after knock-down or inhibition of B23 in the HepG2.2.15 cells. Inhibitors used in this study showed no effect on cell viability by MTT assay . trusted care chiropractic atchisonWeb29 mrt. 2013 · Background: MEF/ELF4 can function as an oncogene. We demonstrated the role of MEF/ELF4 in acute myeloid leukemia.Results: NPM1 inhibited the DNA binding and transcriptional activity of MEF/ELF4 on the HDM2 promoter, whereas NPM1 mutant protein enhanced these activities of MEF/ELF4.Conclusion: MEF/ELF4 activity may be activated … philipp wilhelm von hornickWebNSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50 s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer [1] . NSC348884 (0-6 μM; 24 h) binds with NPM and disrupts NPM oligomer formation [1]. philipp wirthgenWebin vitro nsc348884, which was identified as a putative nucleophosmin small molecular inhibitor, was found to be able to disrupt a hydrophobic pocket that was required for oligomerization, and nsc348884 could also inhibit the cell proliferation in distinct cancer cell lines and disrupt nucleophosmin oligomer formation. moreover, the treatment of several … philipp wimmerWeb23 nov. 2024 · Phase 1/2, Open-Label, Dose Escalation, Dose Expansion Study of Menin Inhibitor DSP-5336 in Adult Patients (pts) with Acute Leukemia with and without Mixed-Lineage Leukemia (MLL)-Rearrangement or Nucleophosmin 1 (NPM1) Mutation philipp wirth