Klf4 control
WebSep 23, 2024 · g, Immunoprecipitation (IP) using KLF4 antibody or IgG in PSC extracts followed by western blot analysis validated the interaction of KLF4 with select factors … WebMay 1, 2007 · The expression of KLF4 has been found to be significantly repressed in human gliomas-associated vascular endothelial cells as compared with that found in non-neoplastic control vascular endothelial cells , suggesting that …
Klf4 control
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WebApr 4, 2024 · KLF4 deficiency impairs neutrophil function in vitro and in vivo. This is the first demonstration that KLF4 plays a crucial role in neutrophils. Abstract Neutrophils are the most abundant white blood cells in circulation and are key components of the innate immune response. WebKLF2 and KLF4 Control Endothelial Identity and Vascular Integrity; FBW7 Regulates Endothelial Functions by Targeting KLF2 for Ubiquitination and Degradation; Flow …
WebF. qRT–PCR analysis of Klf4, Mef2A, Mef2C, and Mef2D (left panels) and WB of KLF4 (right panels) in cultured WT and CCM1 KO ECs treated with either control siRNA (siCTRL) or siRNA directed to any of Mef2A (upper panels), Mef2C (central panels), or Mef2D (lower panels). qRT–PCR data represent the mean ± SD (n = 3) and the fold changes are ... WebApr 4, 2024 · KLF4 deficiency impairs neutrophil function in vitro and in vivo. This is the first demonstration that KLF4 plays a crucial role in neutrophils. Abstract Neutrophils are the …
WebThe negative control was the same skin tissue, with phosphate-buffered saline replacing the KLF4 antibody during the IHC staining. Most of the biopsy samples contained some adjacent noncancerous tissue, though not a lot, and the IHC staining in the study found that all of the noncancerous tissue had low/negative KLF4 expression. WebApr 11, 2024 · To systematically dissect the transcriptomic differences between homeostasis and chronic dry skin at the single-cell level, we carried out scRNA-seq on two biological mixed samples from each group, and each mixed sample contained three mice (Fig. 1 A).After quality control, we obtained 18,578 cells in the AEW groups and 24,160 …
WebJul 17, 2024 · Remarkably, we provide evidence that Klf4 and Oct4 control nearly opposite patterns of gene expression in SMC and based on in vivo ChIP-seq analyses have identified >80 potential Klf4 or Oct4 target genes that may impact SMC phenotypic transitions important in lesion pathogenesis.
WebSep 3, 2024 · Podocyte-specific loss of Klf4 induces podocyte loss and triggers the activation and proliferation of PECs. We recently reported that the podocyte-specific knockdown of Klf4 using the Cre recombinase system (Klf4 ∆Pod) triggered podocyte loss, pathologic glomerular epithelial cell proliferation, and FSGS, leading to kidney dysfunction … small games to play onlineWebDec 11, 2024 · We propose that genes that control adult stem cell homeostasis in organs with slow turnover, such as the prostate, control cancer fate. One such gene, KLF4, overexpressed in murine prostate stem cells, regulates their homeostasis, blocks malignant transformation, and controls the self-renewal of tumor-initiating cells. smallgames.ws pinballWebFeb 24, 2024 · Development of pre-DC2 into CX3CR1 + ESAM-cDC2b but not CX3CR1-ESAM + cDC2a requires the transcription factor KLF4. Last, we show that, under homeostatic … songs that sampled lip glossWebOct 21, 2024 · KLF4 is known to regulate morphogenesis in different tissues and organs, including gut epithelium 13, vascular smooth muscle 14 and cerebral cortex 15. KLF4 is also one of four factors that... small games to play on steamWebSep 11, 2014 · Severe compromise to self-renewal upon KLF4 or TFCP2L1 knockdown is in line with this prediction and provides evidence that reset human PSC are functionally governed by the rewired ground-state transcription factor circuitry. Rescue of TFCP2L1 knockdown cells by ESRRB points to further functional conservation with the mouse ESC … smallgames.ws ballWebKLF4 expression was measured in lung tissue from patients with PAH and normal control subjects. We found that, after hypoxia, right ventricular and PA pressures were significantly higher in KLF4 knockdown animals than controls. Knockdown animals also had more severe pulmonary vascular muscularization and right ventricular hypertrophy. songs that saved my life 2WebMay 18, 2015 · KLF4 has a critical role in regulating SMC phenotype and plaque pathogenesis We have previously shown that KLF4, a cell pluripotency factor 35, is required for SMC phenotypic switching in... songs that sampled genius of love