Klf4 chip
WebMar 7, 2013 · The ChIP-seq data at the Klf4 gene locus revealed a distal region with multiple IRF8 ChIP-seq peaks spanning 120 kb (208 to 328 kb upstream of the Klf4 TSS) (Figure 3A and supplemental Figure 2). Each IRF8 ChIP-seq peak contained composite elements for IRF and ETS. Importantly, this region was tightly associated with high levels of the H3K4me1 ... WebOn the basis of in vivo KLF4 chromatin immunoprecipitation-sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target …
Klf4 chip
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WebAnti-KLF4, Cat. No. ABE2860, is a highly specific rabbit polyclonal antibody that targets Krueppel-like factor 4 (Klf4) and has been tested for use in ChIP-seq, Chromatin Immunoprecipitation (ChIP), Immunoprecipitation, and Western Blotting. - Find MSDS or SDS, a COA, data sheets and more information. WebGet better batch-to-batch reproducibility with a recombinant antibody. Anti-KLF4 antibody [EPR20753-25] (ab214666) Research with confidence – consistent and reproducible results with every batch. Long-term and …
WebKLF4 belongs to the KLF family of transcription factors that regulate several cell functions. It is highly expressed in differentiated epithelial cells of the … WebJun 13, 2011 · KLF4 is essential for IL-4–mediated macrophage M2 polarization. ( A) Impairment of M2 marker gene expression in KLF4-deficient macrophages. PMs isolated from Mye-WT and Mye-KO mice were treated with IL-4 for 16 hours. n = 3 in each group. ( B) KLF4 overexpression enhances M2 gene expression.
KLF4 interacts with the SWI/SNF nucleosome remodeling complex to increase chromatin accessibility Having established that loss of KLF reduces chromatin accessibility, we next sought to identify a... WebDec 3, 2024 · Both KLF4 and Sp5 have been shown to regulate naive pluripotency in part through the transcriptional regulation of Nanog, whose downregulation marks the exit of ESCs from the naive state into a state that is primed for lineage specification 29 – 31. Interestingly, we observed downregulation of both Nanog and Klf4 in I-BRD9-treated ESCs …
WebKLF4 is important in cell-cycle control, cellular differentiation, and carcinogenesis (53–55). We then compared published KLF4 ChIP-seq peaks ( 56 ) with eRNAs and found that KLF4 binding was enriched in eRNA …
WebJun 18, 2024 · KLF4 is a major regulator of the efficacy of EGFR inhibitors in TNBC cells that may underlie the variable effectiveness of such drugs in patients. KLF4 defines the efficacy of the epidermal growth factor receptor inhibitor, erlotinib, in triple-negative breast cancer cells by repressing the EGFR gene Breast Cancer Res. monarch apartments colwoodWebDec 7, 2024 · In combination with KLF4-ChIP seq data, we observed KLF4 binding enrichment at transcription start sites (TSSs) of more than 50% of genes that were significantly changed in NPCs compared with ESCs (fold-change ≥ 2 or ≤–2, P < 0.05) (Figure 1A), as well as at about 80% of gene bodies (Figure 1A), suggesting a possible KLF4 … iapt high intensityWebD–F. ChIP analysis of KLF4 binding to the promoters of Fsp1 (D), Sca1 (E), and Id1 (F) in WT and CCM1 KO cultured ECs. The positions of the putative KLF4 binding sites identified … iapt healthy minds coventryiapt heywoodWebJun 7, 2024 · Figure 1. Dynamic KLF4 binding during reprogramming and association with chromatin accessibility and enhancer activity. a Schematic illustration of the experimental system and strategy.b Tornado plots of KLF4 ChIP-seq signals at different reprogramming stages clustered in four different categories: Early, Mid, Late and Transient KLF4 binding. … iapt health in mind essexWebKLF4 belongs to the Kruppel-like factor (KLF) family, a group of conserved zinc finger TFs that regulates essential biological processes such as proliferation and development. Reflecting pioneer factor activity, KLF4 uses two out of its three zinc fingers to target a GC-rich hexameric motif enriched within nucleosomal targets22 ( Fig. 7.2 C). iapt hertfordshire contactWebklf4-esc.chr17.2m.sam oct4-esc.chr17.2m.sam sox2-esc.chr17.2m.sam These files are originally from the following study investigating the roles that reprogramming factors play when transforming MEF (fibroblasts) into embryonic stem cells. Chronis et al. Cooperative Binding of Transcription Factors Orchestrates Reprogramming iapt healthy minds