WebThe substantial functional group interconversions made to the substituents attached on the main core was explained in the previous chapters. 1 The transformations of acids into acyl chlorides (at C-2 and C-3), trifluoromethyl (CF 3) at C-6 into amine was also mentioned. 1 The 2-hydroxy pyrazolo[1,5-a]pyridine 7 was converted to triflate 8 as an intermediate … Web• Functional Group Interconversion: the operation of writing one functional group for another so that disconnection becomes possible (written with the arrow with FGI on top) • Lets look at our example again: Aromatic acids can be formed from oxidation of methyl groups! Amines are made form hydrogenation of NO 2 groups! N H H O OH FGI O 2N …
Functional group interconversion (fgi) presentation
WebWhich of the following (to be converted by functional group interconversion, FGI) is not a good alternative target for the synthesis of a primary amine, RCH 2 NH 2? a) RCH 2 Cl. … Web• functional group interconversions (FGIs); as stated in lecture 1, these may be regarded as largely tactical in nature, and in a sense are the ‘glue’ which holds the strategy … can you use a graphics card as a capture card
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WebFunctional group strategies. Manipulation of functional groups can lead to significant reductions in molecular complexity. Stereochemical strategies. Numerous chemical … WebFunctional Group Interconversions Reduction Oxidation H 2O H Additions. eliminations, substitutions K + O t Bu K + O t Bu H 2SO 4 (-H 2O) H 2SO 4 (-H 2O) … Websation and redox functional group interconversion) is an at-tractive alternative to the known methods. For example, it is common to take a commercial ketone and yield the tar-geted alcohol 3g by Wittig olefination and BH3 reduction (Scheme 3).46,47 Knoevenagel condensation and O 2/NaBH4 functional group interconversion have the potential to … brit hume corrects tucker