First pass effect 뜻
초회 통과 효과(first pass effect, first pass metabolism, presystemic metabolism)는 약물 대사 현상으로, 특히 경구 투여 시 약물이 온몸 순환에 도달하기 전에 약물의 농도가 크게 감소한다. 일반적으로 간과 장벽(intestinal wall)의 흡수 과정에서 약물이 대사되어 손실된다. 초회 통과 효과의 영향을 크게 받는 주목할 만한 약물은 이미프라민, 모르핀, 프로프라놀롤, 부프레노르핀, 디아제팜, 미다졸람, 페티딘, 테트라하이드로칸나비놀(THC), 에탄올(음주 시 흡수), 시메티딘, 리도카인, 클로르…
First pass effect 뜻
Did you know?
WebThe first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced … WebThe first pass effect, also known as presystemic metabolism or elimination, refers to the metabolism of drugs or chemicals in liver or intestine prior to their reaching the systemic circulation. From: Comprehensive Toxicology, 2010 Download as PDF About this page Minor and Short-Acting Analgesics, Including Opioid Combination Products
WebIn medical terms, first-pass metabolism or presystemic metabolism is defined as the rapid uptake and metabolism of an active compound into inactive compounds by the liver, immediately after enteric absorption … WebFeb 13, 2024 · What is First Pass Effect? The first pass effect is a phenomenon of drug metabolism in which the concentration of a drug, specifically when administered orally, is …
WebThe first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug upon … WebSep 25, 2024 · The first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug …
WebSep 24, 2024 · The first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the …
WebThe first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug upon reaching its site of action or the systemic circulation. The first pass effect is often associated with the liver, as this is a major site of drug metabolism. as milan tottenhamThe first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug, specifically when administered orally, before it reaches the site of action or … See more • ADME, an acronym in pharmacokinetics and pharmacology standing for absorption, distribution, metabolism, and excretion • Biopharmaceutics Classification System • Drug See more • National Library of Medicine, Toxicology Tutor II, Influence of Route of Exposure Archived 2010-06-11 at the Wayback Machine • Herman TF, Santos C. First Pass Effect. 2024 Sep … See more asmin altayWebJul 20, 2024 · The first-pass effect describes inactivation of a drug during the first liver passage. CYP inhibition enhances the effects of drugs that are inactivated via the same CYP, whereas CYP induction reduces drug effects. A large distribution volume points to a deep compartment in which a drug accumulates. Prodrugs are inactive precursors of a … lake ontario map nyWebHepatic first-pass effect: If a drug is rapidly metabolized in the liver, very little or no quantity of the orally administered drug reaches the systemic circulation. So to have desired... asmin koltukWebThe first-pass effect is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction … asmi goitaWebNov 4, 2012 · First-pass effect. When working with oral formulations, you may hear something about the “first-pass” effect. This refers to the drug lost between oral administration and first appearance in the systemic circulation. The drug must survive the milieu in the gastrointestinal (GI) tract, cross the gut wall, and then pass through the … lake ontario marinasWebfirst-pass effect: the intestinal and hepatic degradation or alteration of a drug or substance taken by mouth, after absorption, removing some of the active substance from the blood before it enters the general circulation. Synonym(s): first-pass effect asmin feinkost karlsruhe