WebNov 23, 2024 · FGF23 characteristics and function. FGF23 is produced by the bone osteoblasts and osteocytes, signals through four FGF receptors (FGFR 1, 2, 3, and 4), and requires membrane-bound Klotho for binding in target tissues [ 9 ]. FGFR1 is the predominant receptor mediating phosphaturia in vivo [ 10 ]. WebMar 9, 2024 · Fibroblast growth factor-23 (FGF)-23 is a phosphaturic hormone involved in mineral bone metabolism that helps control phosphate homeostasis and reduces 1,25-dihydroxyvitamin D synthesis. Recent data have highlighted the relevant direct FGF-23 effects on the myocardium, and high plasma levels of FGF-23 have been associated with …
Overview of the FGF23-Klotho axis - PubMed
WebMar 27, 2024 · The role of the interaction between fibroblast growth factor 23-(FGF-23)/Klotho in Klotho-mediated actions is still under debate. The main objective was to ascertain the potential use of plasmatic Klotho and FGF23 as markers for CKD-associated cardiac disease and mortality. WebSep 29, 2024 · The actions of several bone-mineral ion regulators, namely PTH, FGF23, Klotho and 1,25(OH)2 vitamin D (1,25(OH)2D), control calcium and phosphate metabolism, and each of these molecules has additional biological effects related to cell signaling, metabolism and ultimately survival. Therefore, these factors are tightly regulated at … book british gas service online
Plasmatic Klotho and FGF23 Levels as Biomarkers of CKD ... - PubMed
WebMar 22, 2024 · This study aimed at discovering the role of the anti-aging protein α-klotho (KL), which is the co-receptor of fibroblast growth factor-23 (FGF23), in cardiac regeneration, fibrosis, and repair. We found that the anti-apoptotic function of soluble KL in isoproterenol-treated H9c2 cardiomyocytes was independent of FGF23 in vitro. WebDifferent activities of klotho have been described, including activation of fibroblast growth factor (FGF) 23 signaling [12,13], regulation of transient receptor potential cation channel subfamily V member (TRPV) 5 calcium channel [14,15], and inhibition of the insulin and insulin-like growth factor (IGF)-1 pathways [8,16,17]. WebMay 23, 2016 · Fibroblast growth factor 23 (FGF23) is a bone-derived hormone regulating phosphate and vitamin D metabolism. FGF23 works by binding to Klotho-FGF receptor (FGFR) complex. FGF23 reduces serum phosphate level by suppressing the expression of type 2a and 2c sodium-phosphate cotransporters in the renal proximal tubules. godmother\\u0027s 5w