Ctsk macrophage
WebMar 29, 2024 · CTSK cathepsin K Gene ID: 1513, updated on 29-Mar-2024 Gene type: protein coding Also known as: ... Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK/EMT axis and mediates M2 macrophage polarization in castration-resistant prostate cancer. Wu N, Wang Y, Wang K, Zhong B, Liao Y, Liang J, Jiang NWu N, et al. … Web1 day ago · RAW264.7 macrophages, used as a preosteoclast model, were incubated in 89% DMEM medium until they reached 80% confluence, and were then cocultured for 10 days with T cells extracted from the ...
Ctsk macrophage
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WebMay 18, 2012 · Other CtsK-Cre lines have also been reported that are not knock-in lines, but based on Ctsk-Cre transgenic overexpression [50, 51]. These have been used for deletion of Fcgr4 [52], Vdr [53], and ...
WebJul 17, 2013 · Shp2 levels were reduced by >80% in bone-marrow-derived macrophages and osteoclasts in LysM-KO and Ctsk-KO mice (Supplementary Fig. 1a and data not shown). LysM-KO and Ctsk-KO … WebMay 16, 2024 · 37 composition, revealing CtsK as a key molecular determinant of lung phagosomes contributing to 38 phagocytic collagen clearance in lungs. ... 40 Resident tissue macrophages (RTMs) are present in every organ of our body and play an essential role 41 in host protection against infection (Bleriot, Chakarov et al., 2024). As professional ...
WebLung macrophages utilize unique cathepsin K-dependent phagosomal machinery to degrade intracellular collagen. Cathepsin K regulates the tumor growth and metastasis … WebContribute to zhengxj1/Seurat development by creating an account on GitHub.
WebApr 5, 2024 · Importantly, receptor activator of NF-κB (RANK) ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) regulate osteoclastic differentiation and function ... Treatment with RANKL significantly increased the expression of DC-Stamp, TRAP, and Ctsk at 4 days, which was suppressed by RhoA silencing (Additional file 1: …
WebDec 2, 2024 · Secondary osteoporosis has been associated with cancer patients undertaking Doxorubicin (DOX) chemotherapy. However, the molecular mechanisms behind DOX-induced bone loss have not been elucidated. Molecules that can protect against the adverse effects of DOX are still a challenge in chemotherapeutic treatments. We … facebook 06WebApr 4, 2024 · Conditional ablation of PDGF-BB in macrophage-lineage TRAP + cells significantly reduced expression of periostin in periosteum, and an increase of PDGF-BB in Ctsk –/– mice significantly upregulated periostin expression (Figure 6, A and B), suggesting that PDGF-BB induces the periosteal osteogenic microenvironment on the periosteal … facebook 07510WebMay 19, 2024 · In humans, phagosomal CtsK activity was reduced in COPD lung macrophages and non-COPD lung macrophages exposed to cigarette smoke extract. Taken together, this study provides a comprehensive map of how peritoneal, lung and brain tissue environment shapes phagosomal composition, revealing CtsK as a key molecular … does lower taxes help the economyWebApr 13, 2024 · The TRAP, CTSK, and MMP-9 proteins are abundantly expressed in mature osteoclasts, and involved in the osteoclast functions of the bone resorption. A murine macrophage-like cell line, RAW264 cells express RANK at high levels, and are differentiated into osteoclasts after stimulation with RANKL . facebook 007WebWe previously found increased Ctsk expression and secretion in Npc1 / macrophages and increased elastase activity in aortic homogenates of Apoe /, Npc1 / mice.5 To confirm in vivo relevance, we used an affinity-purified antibody18 and found strong CATK immunostaining in the macrophage-rich regions of atherosclerotic plaques in Apoe /, Npc1 mice facebook 090- 刈谷市WebNov 17, 2024 · Introduction. Osteoclasts originate from the monocyte/macrophage lineage and are unique multinucleated giant cells capable of bone resorption. They play … facebook 07WebSep 22, 2024 · All the genes were classified in order to clarify whether CTSK and M2 macrophages were correlated in CRPC. Before establishing the co-expression matrix withed weight, we defined the soft-threshold β as 6 in order to guarantee a scale-free topology. The degree of independence was 0.8 when the soft-threshold β reached 6 (Fig. … facebook 05