Chemotherapy autophagy
WebJan 1, 2015 · Autophagy and Chemotherapy-Induced Apoptosis and Growth Inhibition. Chemotherapy is one of the main options in cancer treatment. However, it has been … WebAug 3, 2024 · Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis. 10(4), e838 (2013). Article Google Scholar Baruch, A. …
Chemotherapy autophagy
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WebOct 25, 2024 · Background: Chemotherapy resistance based on fluorouracil and cisplatin is one of the most encountered postoperative clinical problems in patients diagnosed with gastric cancer (GC), resulting in poor prognosis. Aim of the Study: This study aimed to combine autophagy-related genes (ARGs) to investigate the susceptibility patients with … WebSep 3, 2014 · Given the near-universality of this response, and the extensive literature supporting the cytoprotective functions of chemotherapy-induced autophagy (11–13 ), there has been a tendency to conclude that radiation-induced autophagy is also, by its nature, a cytoprotective response, one that presumably has a role in conferring …
WebOct 14, 2024 · Glioma treatment using targeted chemotherapy is still far from satisfactory due to not only the limited accumulation but also the multiple survival mechanisms of glioma cells, including up-regulation of both autophagy and programmed cell death ligand 1 (PD-L1) expression. Herein, we proposed a combined therapeutic regimen based on … WebSep 7, 2024 · Autophagy is catabolic process by degradation of intracellular components in lysosome including proteins, lipids, and mitochondria in response to nutrient deficiency or stress such as hypoxia or chemotherapy. Increasing evidence suggests that autophagy could induce immune checkpoint proteins (PD-L1, MHC-I/II) degradation of cancer cells, …
WebApr 10, 2024 · Autophagy, an important cellular stress response mechanism, is often exploited by a variety of cancer cells to sustain rapid growth under stresses such as … WebNational Center for Biotechnology Information
WebAutophagy is your body’s cellular recycling system. It allows a cell to disassemble its junk parts and repurpose the salvageable bits and pieces into new, usable cell parts. A cell …
WebApr 5, 2024 · Temozolomide is the first-line chemotherapy drug for glioma, but its drug resistance reduces temozolomide’s clinical efficacy and becomes the principal cause of the failure of glioma chemotherapy. Polyphyllin I (PPI), an active component in Rhizoma Paridis, demonstrates favorable therapeutic actions in diverse malignant neoplasms. my macy\\u0027s account payment onlineWebIn triple-negative breast cancer, the response to autophagy is different from others and dysregulation of this mechanism can mediate drug resistance [365]. eEF2K is a potent regulator of autophagy that determines response of triple-negative breast cancer cells to paclitaxel chemotherapy [366]. The autophagy flux is stimulated in this subtype of ... my macy\\u0027s american express accountWebThe modulation of autophagy holds great promise for improving the efficacy of tumor chemotherapy. Herein, ZONs were verified to enhance chemotherapy in both normal and drug-resistant cancer cells via synergistic autophagy elicitation. Further, this elicitation resulted in tremendous zinc ion release and ROS generation, which accounted for ... my macy\\u0027s credit card loginWebJan 1, 2016 · The primary function of autophagy is to ensure cellular homeostasis under stressful conditions, such as hypoxia and chemo- and radiation therapies (Liu et al., 2013). It is conceivable that autophagy is induced upon treatment of anticancer drugs to protect tumor cells from threatening DNA damage induced by chemotherapeutic drugs. my macy\\u0027s american express account loginWebApr 10, 2024 · Autophagy, an important cellular stress response mechanism, is often exploited by a variety of cancer cells to sustain rapid growth under stresses such as nutrient deprivation and hypoxia. Autophagy also plays a key role in tumor resistance to chemotherapy, radiotherapy or targeted therapy. Inhibition of autophagy is therefore a … my macy\\u0027s card payWebMar 22, 2024 · In addition to chemotherapy, autophagy affects the response of cancer cells to radiotherapy. In this case, autophagy can also induce or inhibit radio-resistance … my macy\\u0027s credit card statementWebMar 15, 2024 · Autophagy inhibition augments chemotherapy. Multiple in vitro and in vivo studies suggest that traditional cytotoxic chemotherapy drugs induce autophagy in multiple cancer types and blocking autophagy with the lysosomal inhibitors chloroquine (CQ) or HCQ can augment chemotherapy efficacy [43]. The most compelling evidence that this … my macy\\u0027s order