Cct369260
WebCCT369260 is an orally active, B-cell lymphoma 6 (BCL6) inhibitor with antitumor activity and an IC50 value of 520 nM. Buy Bcl-2 inhibitor CCT369260 from AbMole BioScience. … http://www.fluoroprobe.com/archives/tag/tetradecanoate
Cct369260
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WebCCT369260 is an orally active, B-cell lymphoma 6 (BCL6) inhibitor with antitumor activity and an IC50 value of 520 nM. Catalog Keywords: (S)-Gossypol (acetic acid) , (S)-(+)-Gossypol acetic acid supplier, Bcl-2 , inhibitors, activators WebPotent, selective and cell-permeable inhibitors of protein function ("chemical probes") are valued reagents in both fundamental and applied biological research, and they are essential for the early stages of drug discovery by allowing preclinical target validation in both academic and industrial laboratories. Donated probe website KCGS website
WebApr 7, 2024 · The transcriptional repressor BCL6 is an oncogenic driver found to be deregulated in lymphoid malignancies. Herein, we report the optimization of our previously reported benzimidazolone mol. glue-type degrader CCT369260 (I) to CCT373566 (II), a highly potent probe suitable for sustained depletion of BCL6 in vivo. We obsd. a sharp … WebCCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC 50 of 520 nM. HY-148281. TMX-2164. Bcl-2 Family Cancer; TMX-2164 is a potent, irreversible B-cell lymphoma 6 (BCL6) inhibitor with an IC 50 value of 152 nM. TMX-2164 displays sustained target engagement ...
WebNov 30, 2024 · We have previously reported the optimization of hit compound CCT365386 (1) yielding potent BCL6 degraders, including cell-active CCT369260. However, in this benzimidazolone series, we were only able to obtain inhibitors of modest potency. We wished to explore alternative core scaffolds with alternative vectors, which would allow … WebMay 26, 2024 · Diffuse large B-cell lymphomas (DLBCLs) are the most common subtype of non-Hodgkin lymphoma.1During the immunological process of affinity maturation, B-cells are required to proliferate rapidly, evade growth checkpoint controls, and tolerate ongoing genomic instability.
WebHerein, we report the optimization of our previously reported benzimidazolone molecular glue-type degrader CCT369260 to CCT373566, a highly potent probe suitable for sustained depletion of BCL6...
WebJaceosidin is a flavonoid obtained from Artemisia vestita, which can activate Bax, down-regulate the expression of McL-1 and C-flip, and induce apoptosis of cancer cells. Jaceosidin has anti-cancer and anti-inflammatory effects, which can reduce the level of inflammatory factors, activate NF-κB, and inhibit the expression of COX-2. scotch soda online espaã±aWebm.cnreagent.com 扫一扫，直接在手机上打开 pregnancy shivers nightWebCCT369260 is a proteasome dependent monovalent BCL6 degrader with IC. 50 = 520 nM (TR-FRET). It is selective by proteomics vs 17 BTB/ZF domain proteins. Closest off … pregnancy shapewear for sidesWebS-6 replacement using PHASER3 with a publicly available BCL6 structure4 (PDB code 3BIM) with ligand and water molecules removed used as molecular replacement model. The protein/ligand structure was manually corrected and rebuilt in COOT5 and refined with BUSTER6 in iterative cycles. Ligand restraints scotch soda mens shirtsWebCCT369260 related products. MedChemExpress provides thousands of inhibitors, modulators and agonists with high purity and quality, excellent customer reviews, precise and professional product citations, tech support and prompt delivery. scotch soda macWebApr 23, 2024 · Abstract. Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a … pregnancy sheltersWebNov 3, 2024 · CCT369260 is an Orally Avtive B-cell Lymphoma 6 (BCL6) Inhibitor with Anti-Tumor Activity 2024-11-03 BCL6 (B-cell lymphoma 6 protein) is a transcriptional repressor. Strikingly, this protein plays a key role in the formation and maintenance of germinal centers during the process of antibody affinity maturation. pregnancy shift dress